the effect of tgf-alpha on neurogenesis in subventricular zone of rat brain after ischemia-reperfusion
نویسندگان
چکیده
introduction: stroke is the third important reason of death in adults and an important cause of adult disability. previous studies suggest that tgf-alpha can induce neurogenesis after stroke. here in, we studied neurogenesis effects of the tgf-alpha on subventricular zone following ischemia-reperfusion. male wistar rats (250-300 g) were divided into ischemia and treatment groups. after induction of ischemia-reperfusions, pbs (phosphate buffer salin) and tgf-alpha 50 ng were injected stereotaxicaly in lateral ventricle in ischemia and treatment respectively. after 12 days, the nestin expression in subventricular zone was assessed by immunohistochemical staining method. results: our results showed that nestin expression increased significantly in treatment group in comparison with ischemia group (p<0.05) . discussion: expression of nestin in svz indicates that tgf- α can stimulate the neural stem cells proliferation after ischemia –reperfusion injury. methods:
منابع مشابه
The Effect of TGF-alpha on Neurogenesis in Subventricular Zone of Rat Brain after Ischemia-Reperfusion
Introduction: Stroke is the third important reason of death in adults and an important cause of adult disability. Previous studies suggest that TGF-alpha can induce neurogenesis after stroke. Here in, we studied neurogenesis effects of the TGF-alpha on subventricular zone following ischemia-reperfusion. Male wistar rats (250-300 g) were divided into ischemia and treatment groups. After inductio...
متن کاملNeurogenesis in dentate subgranular zone and rostral subventricular zone after focal cerebral ischemia in the rat.
Because neurogenesis persists in the adult mammalian brain and can be regulated by physiological and pathological events, we investigated its possible involvement in the brain's response to focal cerebral ischemia. Ischemia was induced by occlusion of the middle cerebral artery in the rat for 90 min, and proliferating cells were labeled with 5-bromo-2'-deoxyuridine-5'-monophosphate (BrdUrd) ove...
متن کاملthe washback effect of discretepoint vs. integrative tests on the retention of content in knowledge tests
در این پایان نامه تاثیر دو نوع تست جزیی نگر و کلی نگر بر به یادسپاری محتوا ارزیابی شده که نتایج نشان دهندهکارایی تستهای کلی نگر بیشتر از سایر آزمونها است
15 صفحه اولthe effect of taftan pozzolan on the compressive strength of concrete in the environmental conditions of oman sea (chabahar port)
cement is an essential ingredient in the concrete buildings. for production of cement considerable amount of fossil fuel and electrical energy is consumed. on the other hand for generating one tone of portland cement, nearly one ton of carbon dioxide is released. it shows that 7 percent of the total released carbon dioxide in the world relates to the cement industry. considering ecological issu...
Bone marrow stromal cells can promote the neurogenesis in subventricular zone in the rat with focal cerebral ischemia
Introdution: Stroke is one of the most common diseases caused by occlusion or rupture of blood vessels in brain. It brings heavily loads for families and societies. Although some new strategies including treatment of tissue plasminogen activator have been applied in the clinic, these methods do not have perfect effect. Accordingly, more effective therapeutic strategies need to be developed...
متن کاملthe effect of e-64 on the developmental competence of sheep cocs during in vitro maturation
in the present study, the effect of e-64 at different concentrations (0.5, 1, 5 and 10 µm) added to (1) the ivm medium on oocyte nuclear maturation and developmental competence of ovine oocytes, and (2) to the ivc medium on embryonic development of ovine embryos were investigated.
منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
basic and clinical neuroscienceجلد ۳، شماره ۲، صفحات ۱۲-۱۵
کلمات کلیدی
میزبانی شده توسط پلتفرم ابری doprax.com
copyright © 2015-2023